LeHavreV1, Main, Exploration, bibRecord, 000313

Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors

Identifieur interne : 000313 ( Main/Exploration ); précédent : 000312; suivant : 000314

Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors

Auteurs : Kristin Kahle-Wrobleski [États-Unis] ; Nicola Coley [France] ; Benoit Lepage [France] ; Christelle Cantet [France] ; Bruno Vellas [France] ; Sandrine Andrieu [France]

Source :

Current Alzheimer Research [ 1567-2050 ] ; 2014.

RBID : PMC:4021450

Abstract

Background: Dementia of the Alzheimer’s type (AD) is defined by both cognitive and functional decline; new criteria allow for identification of milder, non-functionally impaired patients. Understanding loss of autonomy in AD is essential, as later stages represent a significant burden and cost to patients, their families, and society. The purpose of the present analyses was to determine the factor structure of the Alzheimer’s Disease Cooperative Study–Activities of Daily Living Scale (ADCS-ADL) in a cohort of AD patients. Methods: Baseline ADCS-ADL assessments of 734 AD patients from the PLASA study were included in an exploratory factor analysis (EFA). Because the ADCS-ADL was designed to assess change over time, change from baseline scores over 2 years were also analyzed using an EFA. Factorial solutions were evaluated based on cross-loading, non-loadings, and number of items per factor. Results: Mean age at baseline was 79.3, mean MMSE was 19.8 and 73.3‰ of participants were female. Baseline data suggested a 4-factor solution that included factors for basic ADLs (BADLs), domestic/household activities, communication/engagement with the environment, and outside activities. The change scores EFA suggested a 2-factor solution of BADLs and instrumental ADLs (IADLs). Conclusions: Distinct factors of IADLs should be considered for further validation as areas of attention to catch early functional decline.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021450

DOI: 10.2174/1567205011666140317101419
PubMed: 24635843
PubMed Central: 4021450

Affiliations:

Le document en format XML

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<author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors</title>
<author><name sortKey="Kahle Wrobleski, Kristin" sort="Kahle Wrobleski, Kristin" uniqKey="Kahle Wrobleski K" first="Kristin" last="Kahle-Wrobleski">Kristin Kahle-Wrobleski</name>
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<author><name sortKey="Lepage, Benoit" sort="Lepage, Benoit" uniqKey="Lepage B" first="Benoit" last="Lepage">Benoit Lepage</name>
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<author><name sortKey="Cantet, Christelle" sort="Cantet, Christelle" uniqKey="Cantet C" first="Christelle" last="Cantet">Christelle Cantet</name>
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<affiliation><nlm:aff id="aff5">Gerontopole, CHU Toulouse, Department of Geriatric Medicine, F-31059, France, †Members are listed at the end of the manuscript.</nlm:aff>
<wicri:noCountry code="subfield">†Members are listed at the end of the manuscript.</wicri:noCountry>
</affiliation>
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<author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
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<country xml:lang="fr">France</country>
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<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3">University Toulouse III, Toulouse, F-31073, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Toulouse III, Toulouse, F-31073</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Midi-Pyrénées</region>
</placeName>
</affiliation>
<affiliation><nlm:aff id="aff5">Gerontopole, CHU Toulouse, Department of Geriatric Medicine, F-31059, France, †Members are listed at the end of the manuscript.</nlm:aff>
<wicri:noCountry code="subfield">†Members are listed at the end of the manuscript.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name>
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<settlement type="city">Toulouse</settlement>
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<affiliation wicri:level="3"><nlm:aff id="aff3">University Toulouse III, Toulouse, F-31073, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Toulouse III, Toulouse, F-31073</wicri:regionArea>
<placeName><region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Midi-Pyrénées</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff4">CHU Toulouse, Department of Epidemiology and Public Health, Toulouse, F-31073, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Toulouse, Department of Epidemiology and Public Health, Toulouse, F-31073</wicri:regionArea>
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<region type="old region" nuts="2">Midi-Pyrénées</region>
</placeName>
</affiliation>
<affiliation><nlm:aff id="aff5">Gerontopole, CHU Toulouse, Department of Geriatric Medicine, F-31059, France, †Members are listed at the end of the manuscript.</nlm:aff>
<wicri:noCountry code="subfield">†Members are listed at the end of the manuscript.</wicri:noCountry>
</affiliation>
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<series><title level="j">Current Alzheimer Research</title>
<idno type="ISSN">1567-2050</idno>
<idno type="eISSN">1875-5828</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p><italic><underline>Background</underline>
</italic>: 
Dementia of the Alzheimer’s type (AD) is defined by both cognitive and 
functional decline; new criteria allow for identification of milder, 
non-functionally impaired patients. Understanding loss of autonomy in AD is 
essential, as later stages represent a significant burden and cost to patients, 
their families, and society. The purpose of the present analyses was to 
determine the factor structure of the Alzheimer’s Disease Cooperative 
Study–Activities of Daily Living Scale (ADCS-ADL) in a cohort of AD patients. <italic><underline>Methods</underline>
</italic>: Baseline ADCS-ADL assessments of 734 AD patients from the 
PLASA study were included in an exploratory factor analysis (EFA). Because the 
ADCS-ADL was designed to assess change over time, change from baseline scores 
over 2 years were also analyzed using an EFA. Factorial solutions were evaluated 
based on cross-loading, non-loadings, and number of items per factor. <italic><underline>Results</underline>
</italic>: Mean age at baseline was 79.3, mean MMSE was 19.8 and 73.3‰ of 
participants were female. Baseline data suggested a 4-factor solution that 
included factors for basic ADLs (BADLs), domestic/household activities, 
communication/engagement with the environment, and outside activities. The 
change scores EFA suggested a 2-factor solution of BADLs and instrumental ADLs (IADLs).
<italic><underline>Conclusions</underline>
</italic>: Distinct factors of IADLs should be considered for 
further validation as areas of attention to catch early functional decline.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
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<author><name sortKey="Knol, Dl" uniqKey="Knol D">DL Knol</name>
</author>
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<author><name sortKey="Tsolaki, M" uniqKey="Tsolaki M">M Tsolaki</name>
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<author><name sortKey="Frisoni, Gb" uniqKey="Frisoni G">GB  Frisoni</name>
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<author><name sortKey="Downs, Td" uniqKey="Downs T">TD Downs</name>
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<author><name sortKey="Cash, Hr" uniqKey="Cash H">HR Cash</name>
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<author><name sortKey="Grotz, Rc" uniqKey="Grotz R">RC Grotz</name>
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<author><name sortKey="Brody, Em" uniqKey="Brody E">EM Brody</name>
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<author><name sortKey="Bennett, D" uniqKey="Bennett D">D Bennett</name>
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<author><name sortKey="Sano, M" uniqKey="Sano M">M Sano</name>
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<author><name sortKey="Ernesto, C" uniqKey="Ernesto C">C Ernesto</name>
</author>
<author><name sortKey="Thomas, R" uniqKey="Thomas R">R Thomas</name>
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<author><name sortKey="Grundman, M" uniqKey="Grundman M">M  Grundman</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Livingston, G" uniqKey="Livingston G">G Livingston</name>
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<author><name sortKey="Katona, C" uniqKey="Katona C">C Katona</name>
</author>
<author><name sortKey="Roch, B" uniqKey="Roch B">B Roch</name>
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<author><name sortKey="Guilhaum, C" uniqKey="Guilhaum C">C Guilhaum</name>
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<author><name sortKey="Schmitt, Fa" uniqKey="Schmitt F">FA Schmitt</name>
</author>
<author><name sortKey="Olin, Jt" uniqKey="Olin J">JT Olin</name>
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<author><name sortKey="Andrieu, S" uniqKey="Andrieu S">S Andrieu</name>
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<author><name sortKey="Gillette Guyonnet, S" uniqKey="Gillette Guyonnet S">S Gillette-Guyonnet</name>
</author>
<author><name sortKey="Giraudeau, B" uniqKey="Giraudeau B">B Giraudeau</name>
</author>
<author><name sortKey="Cantet, C" uniqKey="Cantet C">C Cantet</name>
</author>
<author><name sortKey="Coley, N" uniqKey="Coley N">N  Coley</name>
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<author><name sortKey="Osborne, Jw" uniqKey="Osborne J">JW Osborne</name>
</author>
</analytic>
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<author><name sortKey="Green, Sb" uniqKey="Green S">SB Green</name>
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<author><name sortKey="Levy, R" uniqKey="Levy R">R Levy</name>
</author>
<author><name sortKey="Lo, Wj" uniqKey="Lo W">WJ Lo</name>
</author>
<author><name sortKey="Scott, L" uniqKey="Scott L">L Scott</name>
</author>
<author><name sortKey="Svetina, D" uniqKey="Svetina D">D  Svetina</name>
</author>
</analytic>
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</author>
<author><name sortKey="Widaman, Kf" uniqKey="Widaman K">KF Widaman</name>
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</author>
<author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name>
</author>
<author><name sortKey="Woods, J" uniqKey="Woods J">J Woods</name>
</author>
<author><name sortKey="Milne, A" uniqKey="Milne A">A Milne</name>
</author>
<author><name sortKey="Katona, C" uniqKey="Katona C">C Katona</name>
</author>
</analytic>
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</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
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<region><li>Indiana</li>
<li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Toulouse</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Indiana"><name sortKey="Kahle Wrobleski, Kristin" sort="Kahle Wrobleski, Kristin" uniqKey="Kahle Wrobleski K" first="Kristin" last="Kahle-Wrobleski">Kristin Kahle-Wrobleski</name>
</region>
</country>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Coley, Nicola" sort="Coley, Nicola" uniqKey="Coley N" first="Nicola" last="Coley">Nicola Coley</name>
</region>
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<name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name>
<name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name>
<name sortKey="Cantet, Christelle" sort="Cantet, Christelle" uniqKey="Cantet C" first="Christelle" last="Cantet">Christelle Cantet</name>
<name sortKey="Cantet, Christelle" sort="Cantet, Christelle" uniqKey="Cantet C" first="Christelle" last="Cantet">Christelle Cantet</name>
<name sortKey="Coley, Nicola" sort="Coley, Nicola" uniqKey="Coley N" first="Nicola" last="Coley">Nicola Coley</name>
<name sortKey="Lepage, Benoit" sort="Lepage, Benoit" uniqKey="Lepage B" first="Benoit" last="Lepage">Benoit Lepage</name>
<name sortKey="Lepage, Benoit" sort="Lepage, Benoit" uniqKey="Lepage B" first="Benoit" last="Lepage">Benoit Lepage</name>
<name sortKey="Lepage, Benoit" sort="Lepage, Benoit" uniqKey="Lepage B" first="Benoit" last="Lepage">Benoit Lepage</name>
<name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
<name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
</country>
</tree>
</affiliations>
</record>

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   |area=    LeHavreV1
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   |texte=   Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors
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Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors

Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors

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Abstract

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